ATM controls meiotic DNA double-strand break formation and recombination and affects synaptonemal complex organization in plants.

ABSTRACT: Meiosis is a specialized cell division that gives rise to genetically distinct gametic cells. Meiosis relies on the tightly controlled formation of DNA double-strand breaks (DSBs) and their repair via homologous recombination for correct chromosome segregation. Like all forms of DNA damage, meiotic DSBs are potentially harmful and their formation activates an elaborate response to inhibit excessive DNA break formation and ensure successful repair. Previous studies established the protein kinase ATM as a DSB sensor and meiotic regulator in several organisms. Here we show that Arabidopsis ATM acts at multiple steps during DSB formation and processing, as well as crossover (CO) formation and synaptonemal complex (SC) organization, all vital for the successful completion of meiosis. We develop

SUBMITTER: Kurzbauer MT 

PROVIDER: S-EPMC8254504 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature