Regulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia.

ABSTRACT:

Background

Microglia play an essential role in the central nervous system immune response. The transcription factor myocyte enhancer factor-2 D (MEF2D) is known to participate in stress regulation in various cell types and is easily activated in microglia. MEF2D has been shown to transcriptionally regulate several cytokine genes in immune cells and directly regulates the inflammatory response, suggesting that MEF2D may act as a key stimulus response regulator of microglia and is involved in the regulation of brain microhomeostasis. To uncover the molecular mechanism of MEF2D in the inflammatory system, in the present study, we investigated the global effect of MEF2D in activated microglia and explored its potential regulatory network.

Methods

Experiments with a recombinant l

SUBMITTER: Lu F 

PROVIDER: S-EPMC8254549 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature