Pulmonary Tuberculosis in Older Adults: Increased Mortality Related to Tuberculosis Within Two Months of Treatment Initiation.

ABSTRACT:

Background

The proportion of tuberculosis (TB) patients who are older adults is increasing worldwide. Nearly 60% of TB patients in Japan are 70 years or older, and the TB incidence rate in Japan is one of the highest among high-income countries. The previous TB treatment guidelines prior to 2018 in Japan recommended excluding pyrazinamide (PZA) from the initial regimen for patients aged over 80 years.

Objectives

We aimed to examine differences in TB treatment outcomes among different age groups, and between those who received PZA and those who did not.

Methods

We performed a retrospective cohort study of patients with pulmonary TB who were managed at a single medical center in Japan. We compared treatment outcomes and adverse events that resulted in treatment interrup

SUBMITTER: Hase I 

PROVIDER: S-EPMC8256198 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature