Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC8256347 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Li Mengyuan M Yan Yu Y Zhang Xinxin X Zhang Yidan Y Xu Xiaohan X Zhang Lei L Lu Liangliang L Wang Jie J Zhang Yazhuo Y Song Qiaoling Q Zhao Chenyang C
Journal of cellular and molecular medicine 20210520 13
JAK/STAT and NFκB signalling pathways play essential roles in regulating inflammatory responses, which are important pathogenic factors of various serious immune-related diseases, and function individually or synergistically. To find prodrugs that can treat inflammation, we performed a preliminary high-throughput screening of 18 840 small molecular compounds and identified scaffold compound L971 which significantly inhibited JAK/STAT and NFκB driven luciferase activities. L971 could inhibit the ...[more]