Sex-based clinical and immunological differences in COVID-19.

ABSTRACT:

Background

Males and females differ in their immunological responses to foreign pathogens. However, most of the current COVID-19 clinical practices and trials do not take the sex factor into consideration.

Methods

We performed a sex-based comparative analysis for the clinical outcomes, peripheral immune cells, and severe acute respiratory syndrome coronavirus (SARS-CoV-2) specific antibody levels of 1558 males and 1499 females COVID-19 patients from a single center. The lymphocyte subgroups were measured by Flow cytometry. The total antibody, Spike protein (S)-, receptor binding domain (RBD)-, and nucleoprotein (N)- specific IgM and IgG levels were measured by chemiluminescence.

Results

We found that male patients had approximately two-fold rates of ICU admission (4.7

SUBMITTER: Huang B 

PROVIDER: S-EPMC8256650 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature