Ontology highlight
ABSTRACT: Lay summary
We examined the role of biological sex in cryptococcal meningitis mortality in a large cohort. Our findings reveal significant differences in inflammatory markers by biological sex. Women have significantly higher mortality due to cryptococcal meningitis that is attributable to anemia at baseline.
SUBMITTER: Stadelman AM
PROVIDER: S-EPMC8257409 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Stadelman Anna M AM Ssebambulidde Kenneth K Tugume Lillian L Pastick Katelyn A KA Hullsiek Kathy Huppler KH Lofgren Sarah S Nuwagira Edwin E Evans Emily E EE Williams Darlisha A DA Muzoora Conrad C Meya David B DB Meya David B DB Rajasingham Radha R Rhein Joshua J Boulware David R DR
Medical mycology 20210701 7
The role of biological sex on clinical outcomes and the pathogenesis of AIDS-related opportunistic infections is unknown. We assessed baseline biomarkers and outcomes between 577 men and 400 women in HIV-related cryptococcal meningitis cohorts in Uganda and South Africa from 2010 to 2017. We compared 10-week mortality by sex via Cox proportional hazards models. The 10-week mortality for women was 50% (198/400) and 43% (247/577) for men. Women had higher risk of death in an unadjusted model (Haza ...[more]