In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201.

ABSTRACT:

Background

Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (²⁰¹Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron capture, releasing around 37 Auger and Coster-Kronig electrons per decay. However, its therapeutic and toxic effects in cancer cells remain largely unexplored. Here, we assess ²⁰¹Tl in vitro kinetics, radiotoxicity and potential for targeted molecular radionuclide therapy, and aim to test the hypothesis that ²⁰¹Tl is radiotoxic only when internalized.

Methods

Breast cancer MDA-MB-231 and prostate cancer DU145 cells were incubated with 200-8000 kBq/mL [²⁰¹Tl]TlCl. Potassium concentration varied between 0 and 25 mM to mo

SUBMITTER: Osytek KM 

PROVIDER: S-EPMC8257813 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature