Cirrhotics with Monocyte Chemotactic Protein 1 Polymorphism are at Higher Risk for Developing Spontaneous Bacterial Peritonitis - A Cohort Study.

ABSTRACT:

Background

Spontaneous bacterial peritonitis (SBP) is a complication of liver cirrhosis and its occurrence portends poor patient survival. There is emerging evidence that genetic predisposition could significantly alter the occurrence and course of SBP. Monocyte chemotactic protein 1 (MCP1) is a potent chemokine that perpetuates the pro-inflammatory milieu in SBP.

Aim

This study aimed at investigating MCP1 genotype polymorphism and its survival impact in patients with decompensated liver cirrhosis.

Methods

We recruited 107 individuals with decompensated liver cirrhosis and categorized them into two groups. Patients having SBP formed the cases (Group 1) and controls were patients without SBP (Group 2). MCP1 polymorphism (-2518A/G) was assessed in both gro

SUBMITTER: Murthy KV 

PROVIDER: S-EPMC8259610 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature