Genetically Predicted Cigarette Smoking in Relation to Risk of Polycystic Ovary Syndrome.

ABSTRACT:

Background

Evidence from observational studies has suggested a link between cigarette smoking and the risk of polycystic ovary syndrome (PCOS). However, it remains uncertain whether the observed relationship is causal or due to biases inherent in observational studies. Therefore, we adopted two-sample Mendelian randomization (MR) design to assess the potential causal association between smoking and the risk of PCOS.

Methods

Summary level data of PCOS was obtained from a genome-wide association study (GWAS) meta-analysis including 4,138 cases and 20,129 controls of European ancestry. Single-nucleotide polymorphisms (SNPs) associated with smoking initiation (n=360) were selected and used as genetic instrumental variables (IVs). MR analysis was performed using inverse-variance

SUBMITTER: Tao Y 

PROVIDER: S-EPMC8259737 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature