Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice.

ABSTRACT: The roles of sex and sex-hormones on the metabolic consequences of intermittent hypoxia (IH, a reliable model of sleep apnea) are unknown. We used intact male or female mice and ovariectomized (OVX) females treated with vehicle (Veh) or estradiol (E₂) and exposed to normoxia (Nx) or IH (6% O₂, 10 cycles/h, 12 h/day, 2 wk). Mice were then fasted for 6 h, and we measured fasting glucose and insulin levels and performed insulin or glucose tolerance tests (ITT or GTT). We also assessed liver concentrations of glycogen, triglycerides (TGs), and expression levels of genes involved in aerobic or anaerobic metabolism. In males, IH lowered fasting levels of glucose and insulin, slightly improved glucose tolerance, but altered glucose tolerance in females. In OVX-Veh females, I

SUBMITTER: Marcouiller F 

PROVIDER: S-EPMC8260369 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature