Ontology highlight
ABSTRACT:
SUBMITTER: Cero C
PROVIDER: S-EPMC8262278 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Cero Cheryl C Lea Hannah J HJ Zhu Kenneth Y KY Shamsi Farnaz F Tseng Yu-Hua YH Cypess Aaron M AM
JCI insight 20210608 11
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial. Herein, using primary human adipocytes from supraclavicular neck fat and immortalized brown/beige adipocytes from deep neck fat from 2 subjects, we demonstrate that the β3-AR plays a critical role in regulating lipolysis, glycolysis, and thermogenesis. Silencing of the β3-AR compromised genes es ...[more]