Ontology highlight
ABSTRACT:
SUBMITTER: Shrestha KS
PROVIDER: S-EPMC8262379 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Shrestha Kul S KS Tuominen Minna M MM Kauppi Liisa L
Mutagenesis 20210701 3
DNA mismatch repair (MMR) proteins play an important role in maintaining genome stability, both in somatic and in germline cells. Loss of MLH1, a central MMR protein, leads to infertility and to microsatellite instability (MSI) in spermatocytes, however, the effect of Mlh1 heterozygosity on germline genome stability remains unexplored. To test the effect of Mlh1 heterozygosity on MSI in mature sperm, we combined mouse genetics with single-molecule PCR that detects allelic changes at unstable mic ...[more]