Ontology highlight
ABSTRACT:
SUBMITTER: Brennan CM
PROVIDER: S-EPMC8262482 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Brennan Christopher M CM Emerson Charles P CP Owens Jane J Christoforou Nicolas N
JCI insight 20210622 12
p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression. Finally, we discuss targeting p38 MAP ...[more]