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An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection.


ABSTRACT: A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological findings revealed cirrhosis and submassive loss and necrosis of hepatocytes. Clinicians should consider the possibility of acute HEV infection as a trigger for acute PBC exacerbation.

SUBMITTER: Koyama M 

PROVIDER: S-EPMC8263169 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection.

Koyama Mizuki M   Yamazaki Tomoo T   Joshita Satoru S   Ito Akihiro A   Ono Kazuyuki K   Watanabe Takayuki T   Yamashita Yuki Y   Sugiura Ayumi A   Kobayashi Mikiko M   Sato Yoshinori Y   Takahashi Masaharu M   Okamoto Hiroaki H   Umemura Takeji T  

Internal medicine (Tokyo, Japan) 20210201 12


A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological find  ...[more]

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