Long-term PM_2.5 exposure before diagnosis is associated with worse outcome in breast cancer.

ABSTRACT:

Purpose

Increasingly epidemiological evidence supports that environmental factors are associated with breast cancer (BC) outcomes after a BC diagnosis. Although evidence suggests that air pollution exposure is associated with higher mortality in women with BC, studies investigating potential mechanisms have been lacking.

Methods

We evaluated women with BC (N = 151) attended at the National Cancer Institute-Mexico from 2012 to 2015. We calculated 1-year average exposures to particulate matter < 2.5 μm (PM_2.5) at home address before diagnosis. We used linear and logistic regression models to determine the associations between PM_2.5 exposure and BC aggressiveness (tumor size, molecular phenotype).

Results

Average annual PM_2.5 exposure of

SUBMITTER: Prada D 

PROVIDER: S-EPMC8263474 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature