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Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi.

ABSTRACT: Four new guaiane-type sesquiterpenes, argyin H-K (1-4), and two known analogues (5 and 6) were isolated from the leaves of Artemisia argyi Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (¹H NMR, ¹³C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of A. argyi, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested in vitro using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC₅₀ values of 15.13-18.63 μM, which were superior to that of oxaliplatin (i.e., IC₅₀ 22.20 μM).

SUBMITTER: Ming W

PROVIDER: S-EPMC8263895 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi.

Ming Wenzhuo W Zhang Yi Y Sun Yiwei Y Bi Guangming G Su Jing J Shao Zhutao Z Meng Dali D

Frontiers in chemistry 20210624

Four new guaiane-type sesquiterpenes, argyin H-K (1-4), and two known analogues (5 and 6) were isolated from the leaves of Artemisia argyi Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (1H NMR, 13C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further ...[more]

PMID: 34249868

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Project description:The Artemisia argyi leaf (AL) has been used as a traditional medicine and food supplement in China and other Asian countries for hundreds of years. Phytochemical studies disclosed that AL contains various bioactive constituents. Among bioactive constituents, phenolic acids have been recognized as the main active compounds in AL. To the best of our knowledge, no research has been focused on extraction method for the bioactive phenolic acids from AL. Nowadays, deep eutectic solvents (DESs) are emerging as a new type of green and sustainable solvent for efficient extraction of bioactive compounds from natural products. In the present study, an environmentally friendly extraction method based on DESs was established to extract bioactive phenolic acids from ALs. Diverse tailor-made solvents, including binary and ternary DESs, were explored for simultaneous extraction of four phenolic acids (3-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid) from AL. The results indicated that the ternary DES composed of a 2:1:2 molar ratio of choline chloride, malic acid, and urea showed enhanced extraction yields for phenolic acids compared with conventional organic solvents and other DESs. Subsequently, the extraction parameters for the four phenolic acids by selected tailor-made DESs, including liquid-solid ratios, water content (%) in the DESs, and extraction time, were optimized using response surface methodology and the optimal extraction conditions were: extraction time, 23.5 min; liquid-solid ratio, 57.5 mL/g (mL of DES/g dry weight of plant material); water content, 54%. The research indicated that DESs were efficient and sustainable green extraction solvents for extraction of bioactive phenolic acids from natural products. Compared to the conventional organic solvents, the DESs have a great potential as possible alternatives to those organic solvents in health-related areas such as food and pharmaceuticals.

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Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi.

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Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of <i>Artemisia argyi</i>.

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