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Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application.

ABSTRACT: N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.

SUBMITTER: Prabhu C P K

PROVIDER: S-EPMC8263923 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application.

Prabhu C P Keshavananda K Nemakal Manjunatha M Managa Muthumuni M Nyokong Tebello T Koodlur Sannegowda Lokesh L

Frontiers in chemistry 20210624

N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine ...[more]

PMID: 34249856

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