Safety of topical corticosteroids in atopic eczema: an umbrella review.

ABSTRACT:

Objective

An umbrella review summarising all safety data from systematic reviews of topical corticosteroids (TCS) in adults and children with atopic eczema.

Methods

Embase, MEDLINE, PubMed, Cochrane Database of Systematic Reviews and the Centre of Evidence Based Dermatology map of eczema systematic reviews were searched until 7 November 2018 and Epistemonikos until 2 March 2021. Reviews were included if they assessed the safety of TCS in atopic eczema and searched >1 database using a reproducible search strategy. Review quality was assessed using version 2 of 'A MeaSurement Tool to Assess systematic Reviews' (AMSTAR 2 tool).

Results

38 systematic reviews included, 34 low/critically low quality. Treatment and follow-up were usually short (2-4 weeks).

Key find

SUBMITTER: Axon E 

PROVIDER: S-EPMC8264889 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature