Association between ICS use and risk of hyperglycemia in COPD patients: systematic review and meta-analysis.

ABSTRACT:

Background

The effect of inhaled corticosteroids (ICS) on risk of hyperglycemia in patients with chronic obstructive pulmonary disease (COPD) remains ambiguous. The aim of this study is to evaluate the association between ICS use and the incidence of hyperglycemia related adverse effects in COPD patients.

Methods

Medline/PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched from inception to 25 May 2020. Randomized controlled trials (RCTs) of ICS versus control (non-ICS) treatment for COPD patients reporting on risk of hyperglycemia were included. The Mantel-Haenszel method with fixed-effects modeling was used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs).

Results

Seventeen RCTs

SUBMITTER: Pu X 

PROVIDER: S-EPMC8265114 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature