Courier service for phosphatidylinositol: PITPs deliver on demand.
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ABSTRACT:
SUBMITTER: Ashlin TG
PROVIDER: S-EPMC8266687 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:BackgroundTo enhance teleconsultation management, demands can be classified into different patterns, and the service of each pattern demand can be improved.MethodsFor the effective teleconsultation classification, a novel ensemble hierarchical clustering method is proposed in this study. In the proposed method, individual clustering results are first obtained by different hierarchical clustering methods, and then ensembled by one-hot encoding, the calculation and division of cosine similarity, and network graph representation. In the built network graph about the high cosine similarity, the connected demand series can be categorized into one pattern. For verification, 43 teleconsultation demand series are used as sample data, and the efficiency and quality of teleconsultation services are respectively analyzed before and after the demand classification.ResultsThe teleconsultation demands are classified into three categories, erratic, lumpy, and slow. Under the fixed strategies, the service analysis after demand classification reveals the deficiencies of teleconsultation services, but analysis before demand classification can't.ConclusionThe proposed ensemble hierarchical clustering method can effectively category teleconsultation demands, and the effective demand categorization can enhance teleconsultation management.
| S-EPMC8379888 | biostudies-literature
Project description:Recently, manufacturing firms and logistics service providers have been encouraged to deploy the most recent features of Information Technology (IT) to prevail in the competitive circumstances of manufacturing industries. Industry 4.0 and Cloud manufacturing (CMfg), accompanied by a service-oriented architecture model, have been regarded as renowned approaches to enable and facilitate the transition of conventional manufacturing business models into more efficient and productive ones. Furthermore, there is an aptness among the manufacturing and logistics businesses as service providers to synergize and cut down the investment and operational costs via sharing logistics fleet and production facilities in the form of outsourcing and consequently increase their profitability. Therefore, due to the Everything as a Service (XaaS) paradigm, efficient service composition is known to be a remarkable issue in the cloud manufacturing paradigm. This issue is challenging due to the service composition problem's large size and complicated computational characteristics. This paper has focused on the considerable number of continually received service requests, which must be prioritized and handled in the minimum possible time while fulfilling the Quality of Service (QoS) parameters. Considering the NP-hard nature and dynamicity of the allocation problem in the Cloud composition problem, heuristic and metaheuristic solving approaches are strongly preferred to obtain optimal or nearly optimal solutions. This study has presented an innovative, time-efficient approach for mutual manufacturing and logistical service composition with the QoS considerations. The method presented in this paper is highly competent in solving large-scale service composition problems time-efficiently while satisfying the optimality gap. A sample dataset has been synthesized to evaluate the outcomes of the developed model compared to earlier research studies. The results show the proposed algorithm can be applied to fulfill the dynamic behavior of manufacturing and logistics service composition due to its efficiency in solving time. The paper has embedded the relation of task and logistic services for cloud service composition in solving algorithm and enhanced the efficiency of resulted matched services. Moreover, considering the possibility of arrival of new services and demands into cloud, the proposed algorithm adapts the service composition algorithm.
| S-EPMC8080429 | biostudies-literature
Project description:Declines in insect pollinators across Europe have raised concerns about the supply of pollination services to agriculture. Simultaneously, EU agricultural and biofuel policies have encouraged substantial growth in the cultivated area of insect pollinated crops across the continent. Using data from 41 European countries, this study demonstrates that the recommended number of honeybees required to provide crop pollination across Europe has risen 4.9 times as fast as honeybee stocks between 2005 and 2010. Consequently, honeybee stocks were insufficient to supply >90% of demands in 22 countries studied. These findings raise concerns about the capacity of many countries to cope with major losses of wild pollinators and highlight numerous critical gaps in current understanding of pollination service supplies and demands, pointing to a pressing need for further research into this issue.
| S-EPMC3885438 | biostudies-literature
Project description:Floating Catchment Area (FCA) methods are a popular tool to investigate accessibility to public facilities, in particular health care services. FCA approaches are attractive because, unlike other accessibility measures, they take into account the potential for congestion of facilities. This is done by 1) considering the population within the catchment area of a facility to calculate a variable that measures level of service, and then 2) aggregating the level of service by population centers subject to catchment area constraints. In this paper we discuss an effect of FCA approaches, an artifact that we term demand and level of service inflation. These artifacts are present in previous implementations of FCA methods. We argue that inflation makes interpretation of estimates of accessibility difficult, which has possible deleterious consequences for decision making. Next, we propose a simple and intuitive approach to proportionally allocate demandand and level of service in FCA calculations. The approach is based on a standardization of the impedance matrix, similar to approaches popular in the spatial statistics and econometrics literature. The result is a more intiuitive measure of accessibility that 1) provides a local version of the provider-to-population ratio; and 2) preserves the level of demand and the level of supply in a system. We illustrate the relevant issues with some examples, and then empirically by means of a case study of accessibility to family physicians in the Hamilton Census Metropolitan Area (CMA), in Ontario, Canada. Results indicate that demand and supply inflation/deflation affect the interpretation of accessibility analysis using existing FCA methods, and that the proposed adjustment can lead to more intuitive results.
| S-EPMC6597094 | biostudies-literature
Project description:Biomass for bioenergy is debated for its potential synergies or tradeoffs with other provisioning and regulating ecosystem services (ESS). This biomass may originate from different production systems and may be purposefully grown or obtained from residues. Increased concerns globally about the sustainable production of biomass for bioenergy has resulted in numerous certification schemes focusing on best management practices, mostly operating at the plot/field scale. In this study, we compare the ESS of two watersheds in the southeastern US. We show the ESS tradeoffs and synergies of plantation forestry, i.e., pine poles, and agricultural production, i.e., wheat straw and corn stover, with the counterfactual natural or semi-natural forest in both watersheds. The plantation forestry showed less distinct tradeoffs than did corn and wheat production, i.e., for carbon storage, P and sediment retention, groundwater recharge, and biodiversity. Using indicators of landscape composition and configuration, we showed that landscape planning can affect the overall ESS supply and can partly determine if locally set environmental thresholds are being met. Indicators on landscape composition, configuration and naturalness explained more than 30% of the variation in ESS supply. Landscape elements such as largely connected forest patches or more complex agricultural patches, e.g., mosaics with shrub and grassland patches, may enhance ESS supply in both of the bioenergy production systems. If tradeoffs between biomass production and other ESS are not addressed by landscape planning, it may be reasonable to include rules in certification schemes that require, e.g., the connectivity of natural or semi-natural forest patches in plantation forestry or semi-natural landscape elements in agricultural production systems. Integrating indicators on landscape configuration and composition into certification schemes is particularly relevant considering that certification schemes are governance tools used to ensure comparable sustainability standards for biomass produced in countries with variable or absent legal frameworks for landscape planning.
| S-EPMC4359142 | biostudies-literature
Project description:This paper presents a limited-stop service for a bus fleet to meet the unbalanced demand of passengers on a bus route and to improve the transit service of the bus route. This strategy includes two parts: a degree assessment of unbalanced passenger demand and an optimization of the limited-stop service. The degree assessment of unbalanced passenger demand, which is based on the different passenger demand between stations and the unbalance of passengers within the station, is used to judge whether implementing the limited-stop service is necessary for a bus route. The optimization of limited-stop service considers the influence of stop skipping action and bus capacity on the left-over passengers to determine the proper skipping stations for the bus fleet serving the entire route by minimizing both the waiting time and in-vehicle time of passengers and the running time of vehicles. A solution algorithm based on genetic algorithm is also presented to evaluate the degree of unbalanced passenger demand and optimize the limited-stop scheme. Then, the proper strategy is tested on a bus route in Changchun city of China. The threshold of degree assessment of unbalanced passenger demand can be calibrated and adapted to different passenger demands.
| S-EPMC5837195 | biostudies-literature
Project description:BackgroundMale circumcision is almost universal in North and West Africa, and practiced for various reasons. Yet there is little documentation on service delivery, clinical procedures, policies, and programmatic strategies. The United Nations Children's Fund (UNICEF) commissioned country program reviews in 2014 to shed light on the delivery of male circumcision services for infants in Cameroon and Senegal.MethodsWe conducted a policy desk review, key informant interviews, and focus group discussions at health centers and in communities. Between December 2014 and January 2015, we conducted 21 key informant interviews (13 with regional and district officers, 5 with national officers, and 3 with UNICEF officials) and 36 focus group discussions (6 with men, 6 with women, 12 with adolescent boys, and 12 with service providers). Some of the men and women were parents of the adolescents who participated in the focus group discussions. In the French-speaking areas, the focus group discussions were conducted in French through an accredited translator, audio recorded, and transcribed into English.ResultsAll of the facilities we visited in Cameroon and Senegal offer medical male circumcision, with 10 out of 12 performing early infant male circumcision (EIMC) routinely. Neither country has policies, guidelines, or strategies for EIMC. The procedure is done mainly by untrained service providers, with some providers using modern circumcision devices. There are no key messages on EIMC for families; the increasing demand for EIMC is led by the community.ConclusionDespite the absence of national policies and strategies, EIMC is routinely offered at all levels of the health care system in Cameroon and Senegal, mainly by untrained service providers. Improving circumcision services will require guidelines for EIMC and improvements in training, equipment, supply chains, recordkeeping, and demand creation.
| S-EPMC4944576 | biostudies-literature
Project description:The dataset presented in this article describe 33 species or varieties of service crops cultivated in population under non-limiting conditions. The description was made at flowering. 41 variables were measured on leaves, stems, roots and seeds. They related to plant phenology (1), morphology (13), physiology (1), biochemistry (18), size (6) and reproduction (2). This dataset is made available to enable comparisons between datasets, extended analysis and meta-analysis on cover crops. The data presented in this article were partly used in the research article entitled "A trait-based characterization of cover plants to assess their potential to provide a set of ecological services in banana cropping systems" (Damour et al., 2014).
| S-EPMC7298398 | biostudies-literature
Project description:Background Improving the availability and usability of data and analytical tools is a critical precondition for further advancing modern biological and biomedical research. For instance, one of the many ramifications of the COVID-19 global pandemic has been to make even more evident the importance of having bioinformatics tools and data readily actionable by researchers through convenient access points and supported by adequate IT infrastructures. One of the most successful efforts in improving the availability and usability of bioinformatics tools and data is represented by the Galaxy workflow manager and its thriving community. In 2020 we introduced Laniakea, a software platform conceived to streamline the configuration and deployment of “on-demand” Galaxy instances over the cloud. By facilitating the set-up and configuration of Galaxy web servers, Laniakea provides researchers with a powerful and highly customisable platform for executing complex bioinformatics analyses. The system can be accessed through a dedicated and user-friendly web interface that allows the Galaxy web server’s initial configuration and deployment. Results “Laniakea@ReCaS”, the first instance of a Laniakea-based service, is managed by ELIXIR-IT and was officially launched in February 2020, after about one year of development and testing that involved several users. Researchers can request access to Laniakea@ReCaS through an open-ended call for use-cases. Ten project proposals have been accepted since then, totalling 18 Galaxy on-demand virtual servers that employ ~ 100 CPUs, ~ 250 GB of RAM and ~ 5 TB of storage and serve several different communities and purposes. Herein, we present eight use cases demonstrating the versatility of the platform. Conclusions During this first year of activity, the Laniakea-based service emerged as a flexible platform that facilitated the rapid development of bioinformatics tools, the efficient delivery of training activities, and the provision of public bioinformatics services in different settings, including food safety and clinical research. Laniakea@ReCaS provides a proof of concept of how enabling access to appropriate, reliable IT resources and ready-to-use bioinformatics tools can considerably streamline researchers’ work.
| S-EPMC8574934 | biostudies-literature
Project description:Meeting current global passenger and freight transport energy service demands accounts for 20% of annual anthropogenic CO2 emissions, and mitigating these emissions remains a considerable challenge for climate policy. Pursuant to this, energy service demands play a critical role in the energy systems and integrated assessment models but fail to get the attention they warrant. This study introduces a novel custom deep learning neural network architecture (called TrebuNet) that mimics the physical process of firing a trebuchet to model the nuanced dynamics inherent in energy service demand estimation. Here we show, how TrebuNet is designed, trained, and used to estimate transport energy service demand. We find that the TrebuNet architecture shows superior performance compared with traditional multivariate linear regression and state of the art methods like densely connected neural network, Recurrent Neural Network, and Gradient Boosted machine learning algorithms when evaluated for regional demand projection for all modes of transport demands at short, decadal, and medium-term time horizons. Finally, TrebuNet introduces a framework to project energy service demand for regions having multiple countries spanning different socio-economic development pathways which can be replicated for wider regression-based task for timeseries having non-uniform variance.
| S-EPMC9981557 | biostudies-literature