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Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice.

ABSTRACT: Amyloid A (AA) amyloidosis is a lethal disease characterized by systemic AA amyloid deposition, and is reported in many animal species. Despite experiments have shown that AA amyloidosis can be transmitted orally, horizontal transmission and cross-species transmission are concerns, the transmission mechanism has been unknown. In this study, we examined the oral transmission efficiency of AA amyloidosis using oxazolone-induced gastrointestinal disorder mice. As a result, the upper or lower gastrointestinal disorder groups developed more severe amyloid deposition in systemic tissues than the group without gastrointestinal disorders. The results of this study suggest that gastrointestinal damage promotes the oral transmission of AA amyloidosis.

SUBMITTER: Kobayashi H

PROVIDER: S-EPMC8267199 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice.

Kobayashi Hiroto H Iwaide Susumu S Ujike Naoki N Murakami Tomoaki T

The Journal of veterinary medical science 20210420 6

Amyloid A (AA) amyloidosis is a lethal disease characterized by systemic AA amyloid deposition, and is reported in many animal species. Despite experiments have shown that AA amyloidosis can be transmitted orally, horizontal transmission and cross-species transmission are concerns, the transmission mechanism has been unknown. In this study, we examined the oral transmission efficiency of AA amyloidosis using oxazolone-induced gastrointestinal disorder mice. As a result, the upper or lower gastro ...[more]

PMID: 33883362

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