Exhaled Hydrogen as a Marker of Intestinal Fermentation Is Associated with Diarrhea in Kidney Transplant Recipients.

ABSTRACT:

Background

Diarrhea is common among kidney transplant recipients (KTR). Exhaled hydrogen (H₂) is a surrogate marker of small bowel dysbiosis, which may drive diarrhea. We studied the relationship between exhaled H₂ and diarrhea in KTR, and explored potential clinical and dietary determinants.

Methods

Clinical, laboratory, and dietary data were analyzed from 424 KTR participating in the TransplantLines Biobank and Cohort Study (NCT03272841). Fasting exhaled H₂ concentration was measured using a model DP Quintron Gas Chromatograph. Diarrhea was defined as fast transit time (types 6 and 7 according to the Bristol Stool Form Scale, BSFS) of 3 or more episodes per day. We studied the association between exhaled H₂ and diarrhea with mult

SUBMITTER: Rodrigues FG 

PROVIDER: S-EPMC8267713 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature