TBX5-AS1, an enhancer RNA, is a potential novel prognostic biomarker for lung adenocarcinoma.

ABSTRACT:

Background

Enhancer RNAs (eRNAs) are demonstrated to be closely associated with tumourigenesis and cancer progression. However, the role of eRNAs in lung adenocarcinoma (LUAD) remains largely unclear. Thus, a comprehensive analysis was constructed to identify the key eRNAs, and to explore the clinical utility of the identified eRNAs in LUAD.

Methods

First, LUAD expression profile data from the Cancer Genome Atlas (TCGA) dataset and eRNA-relevant information were integrated for Kaplan-Meier survival analysis and Spearman's correlation analysis to filtered the key candidate eRNAs that was associated with survival rate and their target genes in LUAD. Then, the key eRNA was selected for subsequent clinical correlation analysis. KEGG pathway enrichment analyses were undertaken to

SUBMITTER: Cheng L 

PROVIDER: S-EPMC8268367 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature