Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Perez O
PROVIDER: S-EPMC8268953 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
López-Pérez Óscar Ó Sanz-Rubio David D Hernaiz Adelaida A Betancor Marina M Otero Alicia A Castilla Joaquín J Andréoletti Olivier O Badiola Juan José JJ Zaragoza Pilar P Bolea Rosa R Toivonen Janne M JM Martín-Burriel Inmaculada I
International journal of molecular sciences 20210625 13
Diagnosis of transmissible spongiform encephalopathies (TSEs), or prion diseases, is based on the detection of proteinase K (PK)-resistant PrP<sup>Sc</sup> in post-mortem tissues as indication of infection and disease. Since PrP<sup>Sc</sup> detection is not considered a reliable method for in vivo diagnosis in most TSEs, it is of crucial importance to identify an alternative source of biomarkers to provide useful alternatives for current diagnostic methodology. Ovine scrapie is the prototype of ...[more]