Ontology highlight
ABSTRACT:
SUBMITTER: Cihlova B
PROVIDER: S-EPMC8270262 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Cihlova Bara B Huskova Andrea A Böserle Jiri J Nencka Radim R Boura Evzen E Silhan Jan J
Molecules (Basel, Switzerland) 20210622 13
Spanish flu, polio epidemics, and the ongoing COVID-19 pandemic are the most profound examples of severe widespread diseases caused by RNA viruses. The coronavirus pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) demands affordable and reliable assays for testing antivirals. To test inhibitors of viral proteases, we have developed an inexpensive high-throughput assay based on fluorescent energy transfer (FRET). We assayed an array of inhibitors for papain-like prot ...[more]