Spatially resolved sampling for untargeted metabolomics: A new tool for salivomics.

ABSTRACT: Saliva is a complex bodily fluid composed of metabolites secreted by major and minor glands, as well as by-products of host oral cells, oral bacteria, gingival crevicular fluid, and exogenous compounds. Major salivary glands include the paired parotid, submandibular, and sublingual glands. The secreted fluids of the salivary glands vary in composition, flow rate, site of release, and clearance suggesting that different types of saliva fulfill different functions and therefore can provide unique biological information. Consequently, for the comprehension of the functionality of the salivary components, spatially resolved investigations are warranted. To understand and comprehensively map the highly heterogeneous environment of the oral cavity, advanced spatial sampling techniques for metabo

SUBMITTER: Ciurli A 

PROVIDER: S-EPMC8271151 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature