Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC8271850 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
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Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.
Chen Xushan X Zhang Huimin H Yang Xin X Zhang Wuhong W Jiang Ming M Wen Ting T Wang Jie J Guo Rui R Liu Hanjiao H
Molecules (Basel, Switzerland) 20210701 13
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydro ...[more]
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