Unknown

Dataset Information

0

Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.


ABSTRACT: Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.

SUBMITTER: Chen X 

PROVIDER: S-EPMC8271850 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8238405 | biostudies-literature
| S-EPMC8693078 | biostudies-literature
| S-EPMC8365451 | biostudies-literature
| S-EPMC6914676 | biostudies-literature
| S-EPMC10213409 | biostudies-literature
| S-EPMC7044469 | biostudies-literature
| S-EPMC8061386 | biostudies-literature
| S-EPMC8071097 | biostudies-literature
| S-EPMC6124756 | biostudies-literature
| S-EPMC6940869 | biostudies-literature