Ontology highlight
ABSTRACT: Background
Esophageal atresia (EA) affects around 2.3-2.6 per 10,000 births world-wide. Infants born with this condition require surgical correction soon after birth. Most survival studies of infants with EA are locally or regionally based. We aimed to describe survival across multiple world regions.Methods
We included infants diagnosed with EA between 1980 and 2015 from 24 birth defects surveillance programs that are members of the International Clearinghouse for Birth Defects Surveillance and Research. We calculated survival as the proportion of liveborn infants alive at 1 month, 1- and 5-years, among all infants with EA, those with isolated EA, those with EA and additional anomalies or EA and a chromosomal anomaly or genetic syndrome. We also investigated trends in survival over the decades, 1980s-2010s.Results
We included 6,466 liveborn infants with EA. Survival was 89.4% (95% CI 88.1-90.5) at 1-month, 84.5% (95% CI 83.0-85.9) at 1-year and 82.7% (95% CI 81.2-84.2) at 5-years. One-month survival for infants with isolated EA (97.1%) was higher than for infants with additional anomalies (89.7%) or infants with chromosomal or genetic syndrome diagnoses (57.3%) with little change at 1- and 5-years. Survival at 1 month improved from the 1980s to the 2010s, by 6.5% for infants with isolated EA and by 21.5% for infants with EA and additional anomalies.Conclusions
Almost all infants with isolated EA survived to 5 years. Mortality was higher for infants with EA and an additional anomaly, including chromosomal or genetic syndromes. Survival improved from the 1980s, particularly for those with additional anomalies.
SUBMITTER: Bell JC
PROVIDER: S-EPMC8273078 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Bell Jane C JC Baynam Gareth G Bergman Jorieke E H JEH Bermejo-Sánchez Eva E Botto Lorenzo D LD Canfield Mark A MA Dastgiri Saeed S Gatt Miriam M Groisman Boris B Hurtado-Villa Paula P Kallen Karin K Khoshnood Babak B Konrad Victoria V Landau Danielle D Lopez-Camelo Jorge S JS Martinez Laura L Morgan Margery M Mutchinick Osvaldo M OM Nance Amy E AE Nembhard Wendy W Pierini Anna A Rissmann Anke A Shan Xiaoyi X Sipek Antonin A Szabova Elena E Tagliabue Giovanna G Yevtushok Lyubov S LS Zarante Ignacio I Nassar Natasha N
Birth defects research 20210318 12
<h4>Background</h4>Esophageal atresia (EA) affects around 2.3-2.6 per 10,000 births world-wide. Infants born with this condition require surgical correction soon after birth. Most survival studies of infants with EA are locally or regionally based. We aimed to describe survival across multiple world regions.<h4>Methods</h4>We included infants diagnosed with EA between 1980 and 2015 from 24 birth defects surveillance programs that are members of the International Clearinghouse for Birth Defects S ...[more]