Dataset Information

Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services.

ABSTRACT:

Introduction

Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute hepatitis in Brazil need to be re-evaluated regarding the different hepatotropic agent (hepatitis A to E virus) frequencies, as well as other agents that can cause similar clinical conditions, such as Herpes Simplex Virus 1 and 2(HSV1, HSV2), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Human Herpes Virus 6 and 7 (HHV6, HHV7), arbovirus (yellow fever, dengue, chikungunya, Zika), parvovirus B19, adenovirus, parechovirus, enterovirus, HIV, leptospirosis, toxoplasmosis and syphilis, in addition to autoimmune hepatitis. In this context, the primary aim of this study is the clinical-epidemiological and molecular characterisation of acute viral hepatitis in Brazilian health services from all geographical regions of the country. The present article describes the study protocol.

Methods and analysis

This study will evaluate 2280 patients with symptoms and/or signs suggestive of acute liver disease in Brazilian health institutions in all five geographic Brazilian regions. Demographic, epidemiological and clinical data will be collected, as well as blood samples to be analysed at Hospital Israelita Albert Einstein Clinical Laboratory.

Ethics and dissemination

Ethics approval was obtained at the national research ethics committee (Conselho Nacional de Ética em Pesquisa- CONEP-CAAE 00952818.4.1001.0071) and at all participating sites. Results will be published in journals and presented at scientific meetings.

SUBMITTER: Sitnik R

PROVIDER: S-EPMC8273480 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Publications

Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services.

Sitnik Roberta R Maluf Maira Marranghello MM Oliveira Ketti G KG Siqueira Ricardo Andreotti RA Ferreira Carlos Eduardo Dos Santos CEDS Mangueira Cristóvão Luis Pitangueira CLP Azevedo Raymundo Soares RS Ferraz Maria Lucia Cardoso Gomes MLCG Correa Maria Cassia Jacintho Mendes MCJM Ferreira Paulo Roberto Abrão PRA Mendes Pereira Gerson Fernando GF de Souza Flávia Moreno Alves FMA Pimenta Cristina C Pinho João Renato Rebello JRR

BMJ open 20210709 7

<h4>Introduction</h4>Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute hepatitis in Brazil need to be re-evaluated regarding the different hepatotropic agent (hepatitis A to E virus) frequencies, as well as other agents that can cause similar clinical conditions, such ...[more]

PMID: 34244259

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Dataset Information

Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services.

Introduction

Methods and analysis

Ethics and dissemination

Publications

Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services.

Similar Datasets

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