Circular RNA hsa_circ_0001874 is an indicator for gastric cancer.

ABSTRACT:

Background

Recent studies have indicated that circular RNAs (circRNAs) are novel endogenous RNAs whose 5' and 3' ends are covalently linked and play critical roles in gastric carcinogenesis. However, the significance of circRNA hsa_circ_0001874 in gastric cancer (GC) is still unclear.

Methods

Therefore, we first detected hsa_circ_0001874 levels in GC cell lines and tissues and analyzed their potential correlation with clinicopathological factors. Then, a receiver operating characteristic (ROC) curve was established to evaluate its clinical value. Finally, we further predicted the biological functions of this molecule by bioinformatics analysis.

Results

Our data showed that as an indicator, hsa_circ_0001874 expression was significantly decreased in 78.02% (71/91) of th

SUBMITTER: Ye Q 

PROVIDER: S-EPMC8274977 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature