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Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz.

ABSTRACT: Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9 - 13), seven 7,17-seco-aconitine-type alkaloids (1 - 4, 6 - 8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum flavum Hand.-Mazz. In which, flavumolines A - D (1 - 4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca_v3.1 low voltage-gated Ca²⁺ channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested.

SUBMITTER: Zhang N

PROVIDER: S-EPMC8275754 | biostudies-literature |

REPOSITORIES: biostudies-literature

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