Effects of gastric bypass surgery on expression of glucose transporters and fibrotic biomarkers in kidney of diabetic fatty rats.

ABSTRACT:

Background

Diabetic nephropathy is the leading cause of chronic kidney disease. Observational studies suggest Roux-en-Y gastric bypass (RYGB) reduces progression of diabetic nephropathy.

Objectives

To unravel the mechanisms by which RYGB is beneficial and protective for diabetic nephropathy.

Setting

Academic laboratories.

Methods

Forty-eight Zucker diabetic fatty rats were randomized to RYGB, sham surgery (SHAM), or pair-fed (PF) groups. An oral glucose tolerance test was performed at 25 days post intervention and kidneys were harvested at 30 days. Primary outcome measures included expression of key genes and proteins in the glucose transport, oxidative stress, inflammation, and fibrosis pathways.

Results

Thirty days post intervention, RYGB rats weighed

SUBMITTER: Vangoitsenhoven R 

PROVIDER: S-EPMC8276306 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature