Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies.

ABSTRACT: To evaluate the implication of ¹⁸F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, and ¹⁸F-Florbetaben (FBB) PET. DAT- and FDG-uptake and FDG/DAT ratio were measured in the anterior and posterior striatum. The first principal component (PC1) of FDG subject residual profiles was identified for each subject. Receiver operating characteristic curve analyses for the diagnosis of DLB were performed using FDG- and DAT-PET biomarkers as predictors, and general linear models for motor severity and cognitive scores were performed adding FBB standardized uptake value ratio a

SUBMITTER: Kang SW 

PROVIDER: S-EPMC8277897 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature