Coffee Consumption Modulates Amoxicillin-Induced Dysbiosis in the Murine Gut Microbiome.

ABSTRACT: The microbiome is essential for host health, and perturbations resulting from antibiotic use can lead to dysbiosis and disease. Diet can be a powerful modulator of microbiome composition and function, with the potential to mitigate the negative effects of antibiotic use. Thus, it is necessary to study the impacts of diet and drug interactions on the gut microbiome. Coffee is a commonly consumed beverage containing many compounds that have the potential to affect the microbiome, including caffeine, polyphenols, and fiber. We supplemented mice with caffeinated and decaffeinated coffee in conjunction with amoxicillin, and used 16S rRNA amplicon sequencing of fecal samples to investigate changes in diversity and composition of the murine fecal microbiome. We found that antibiotics, regardless

SUBMITTER: Diamond E 

PROVIDER: S-EPMC8278525 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature