Grid search approach to discriminate between old and recent inbreeding using phenotypic, pedigree and genomic information.

ABSTRACT:

Background

Although inbreeding caused by the mating of animals related through a recent common ancestor is expected to have more harmful effects on phenotypes than ancient inbreeding (old inbreeding), estimating these effects requires a clear definition of recent (new) and ancient (old) inbreeding. Several methods have been proposed to classify inbreeding using pedigree and genomic data. Unfortunately, these methods are largely based on heuristic criteria such as the number of generations from a common ancestor or length of runs of homozygosity (ROH) segments. To mitigate these deficiencies, this study aimed to develop a method to classify pedigree and genomic inbreeding into recent and ancient classes based on a grid search algorithm driven by the assumption that new inbreeding te

SUBMITTER: Sumreddee P 

PROVIDER: S-EPMC8278650 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature