Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu₂/mGlu₄ receptor heterodimers.

ABSTRACT: Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies have suggested that mGluRs can form functional heterodimers in cell lines. Using selective allosteric ligands, ex vivo brain slice electrophysiology, and optogenetic approaches, we found that two mGluR subtypes-mGluR2 and mGluR4 (or mGlu₂ and mGlu₄)-exist as functional heterodimers that regulate excitatory transmission in a synapse-specific manner within the rodent medial prefrontal cortex (mPFC). Activation of mGlu₂/mGlu₄ heterodimers inhibited glutamatergic signaling at thalamo-mPFC synapses but no

SUBMITTER: Xiang Z 

PROVIDER: S-EPMC8279257 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature