Ontology highlight
ABSTRACT:
SUBMITTER: Al Alwan B
PROVIDER: S-EPMC8280113 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Al Alwan Bader B AbuZineh Karmen K Nozue Shuho S Rakhmatulina Aigerim A Aldehaiman Mansour M Al-Amoodi Asma S AS Serag Maged F MF Aleisa Fajr A FA Merzaban Jasmeen S JS Habuchi Satoshi S
Communications biology 20210714 1
Hematopoietic stem/progenitor cell (HSPC) and leukemic cell homing is an important biological phenomenon that occurs through key interactions between adhesion molecules. Tethering and rolling of the cells on endothelium, the crucial initial step of the adhesion cascade, is mediated by interactions between selectins expressed on endothelium to their ligands expressed on HSPCs/leukemic cells in flow. Although multiple factors that affect the rolling behavior of the cells have been identified, mole ...[more]