Ontology highlight
ABSTRACT:
SUBMITTER: Cushion MT
PROVIDER: S-EPMC8280485 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Cushion Melanie T MT Kumar Parag P Lu Ruying R Ashbaugh Alan A Adeojo Lilian W LW Alfaro Raul R Mannino Raphael R Tramont Edmund E Kovacs Joseph A JA
The Journal of infectious diseases 20210701 2
Although atovaquone is effective in treating and preventing Pneumocystis pneumonia (PCP), its use is limited by nonlinear absorption and adverse events. The current study was undertaken to examine the activity of encochleated atovaquone (eATQ), a novel lipid-crystal nanoparticle formulation, in a mouse model of PCP. eATQ 100-200 mg was superior to commercially available atovaquone at 14 days in decreasing total Pneumocystis nuclei and asci. eATQ plus anidulafungin reduced nuclei significantly be ...[more]