Circulating white blood cells and lung function impairment: the observational studies and Mendelian randomization analysis.

ABSTRACT:

Background

Circulating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed to evaluate independent effects and causal relationships of WBC subtypes with lung function.

Methods

The 19,159 participants from NHANES 2011-2012 (n = 3570), coke-oven workers (COW, n = 1762) and Dongfeng-Tongji (DFTJ, n = 13,827) cohorts were included in the observational studies. The associations between circulating counts of WBC subtypes and prebronchodilator lung function were evaluated by linear regression models and LASSO regression was used to select effective WBC subtypes. Summary statistics for WBC-associated SNPs were extracted from literature, and Mendelian randomization (MR) analysis with i

SUBMITTER: Wu X 

PROVIDER: S-EPMC8280897 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature