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Imidazolium labelling permits the sensitive mass-spectrometric detection of N-glycosides directly from serum.


ABSTRACT: A novel imidazolium derivative (GITag) shows superior ionisation and consequently allows increased mass spectrometric detection capabilities of oligosaccharides and N-glycans. Here we demonstrate that human serum samples can be directly labelled by GITag on a MALDI target plate, abrogating prevalently required sample pretreatment or clean-up steps.

SUBMITTER: Zhang YY 

PROVIDER: S-EPMC8280963 | biostudies-literature |

REPOSITORIES: biostudies-literature

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