Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1.

ABSTRACT:

Background

No prognostic score is currently available for long-term survival in autoimmune hepatitis (AIH) patients.

Objective

The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis.

Methods

The prognostic score was developed using uni- & multivariate Cox regression in a 4-center Dutch cohort and validated in an independent 6-center Belgian cohort.

Results

In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow-up 118 months; interquartile range 60-202 months). In multivariate analysis age (hazard ratio [HR] 1.045; p < 0.001), non-caucasian ethnicity (HR 1.897; p = 0.045), cirrhosis (HR 3.266; p < 0.001) and alanine aminotransferase level (HR 0.725; p = 0.003

SUBMITTER: Biewenga M 

PROVIDER: S-EPMC8281048 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature