Predictive Modeling of Secondary Pulmonary Hypertension in Left Ventricular Diastolic Dysfunction.

ABSTRACT: Diastolic dysfunction is a common pathology occurring in about one third of patients affected by heart failure. This condition may not be associated with a marked decrease in cardiac output or systemic pressure and therefore is more difficult to diagnose than its systolic counterpart. Compromised relaxation or increased stiffness of the left ventricle induces an increase in the upstream pulmonary pressures, and is classified as secondary or group II pulmonary hypertension (2018 Nice classification). This may result in an increase in the right ventricular afterload leading to right ventricular failure. Elevated pulmonary pressures are therefore an important clinical indicator of diastolic heart failure (sometimes referred to as heart failure with preserved ejection fraction, HFpEF),

SUBMITTER: Harrod KK 

PROVIDER: S-EPMC8281259 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature