In situ transplantation of adipose-derived stem cells via photoactivation improves glucose metabolism in obese mice.

ABSTRACT:

Background

Accumulating evidence suggests that enhanced adipose tissue macrophages (ATMs) are associated with metabolic disorders in obesity and type 2 diabetes. However, therapeutic persistence and reduced homing stem cell function following cell delivery remains a critical hurdle for the clinical translation of stem cells in current approaches.

Methods

We demonstrate that the effect of a combined application of photoactivation and adipose-derived stem cells (ASCs) using transplantation into visceral epididymal adipose tissue (EAT) in obesity. Cultured ASCs were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet (ND).

Results

In diet-induced obesity, implantation of light-treated ASCs improved glucose tolerance and ameliorated systemi

SUBMITTER: Zhu L 

PROVIDER: S-EPMC8281693 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature