Heterotypic tumor models through freeform printing into photostabilized granular microgels.
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ABSTRACT:
SUBMITTER: Molley TG
PROVIDER: S-EPMC8282188 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Heterotypic tumor models through freeform printing into photostabilized granular microgels.
Molley Thomas G TG Jalandhra Gagan K GK Nemec Stephanie R SR Tiffany Aleczandria S AS Patkunarajah Amrutha A Poole Kate K Harley Brendan A C BAC Hung Tzong-Tyng TT Kilian Kristopher A KA
Biomaterials science 20210601 12
The tissue microenvironment contains a complex assortment of multiple cell types, matrices, and vessel structures, which is difficult to reconstruct in vitro. Here, we demonstrate model tumor microenvironments formed through direct writing of vasculature channels and tumor cell aggregates, within a cell-laden microgel matrix. Photocrosslinkable microgels provide control over local and global mechanics, while enabling the integration of virtually any cell type. Direct writing of a Pluronic sacrif ...[more]
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