The Potential Effect of Rhizoma coptidis on Polycystic Ovary Syndrome Based on Network Pharmacology and Molecular Docking.

ABSTRACT:

Background

Rhizoma coptidis (RC) showed a significant effect on PCOS, but its mechanism in PCOS remains unclear.

Methods

The components of RC were searched by TCMSP. The Smiles number of the active ingredients was queried through PubChem, and the predicted targets were obtained from the SwissTargetPrediction database. The DrugBank, GeneCards, and DisGeNET databases were retrieved to acquire the related targets of PCOS. Then, the network of compound-target was constructed. The core targets were analyzed using protein-protein interaction (PPI) analysis, and the binding activities were verified by molecular docking. The enriched pathways of key targets were examined by GO and KEGG.

Results

13 components and 250 targets of RC on PCOS were screened. The core network

SUBMITTER: Duan L 

PROVIDER: S-EPMC8282388 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature