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Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas.


ABSTRACT: Schwannomas are benign neoplasms that can cause gain- and loss-of-function neurological phenotypes, including severe, intractable pain. To investigate the molecular mechanisms underlying schwannoma-associated pain we compared the RNA sequencing profile of painful and non-painful schwannomas from NF2 patients. Distinct segregation of painful and non-painful tumors by gene expression patterns was observed. Differential expression analysis showed the upregulation of fibroblast growth factor 7 (FGF7) in painful schwannomas. Behavioral support for this finding was observed using a xenograft human NF2-schwannoma model in nude mice. In this model, over-expression of FGF7 in intra-sciatically implanted NF2 tumor cells generated pain behavior compared with controls.

SUBMITTER: Kukutla P 

PROVIDER: S-EPMC8283170 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas.

Kukutla Phanidhar P   Ahmed Sherif G SG   DuBreuil Daniel M DM   Abdelnabi Ahmed A   Cetinbas Murat M   Fulci Giulia G   Aldikacti Berent B   Stemmer-Rachamimov Anat A   Plotkin Scott R SR   Wainger Brian B   Sadreyev Ruslan I RI   Brenner Gary J GJ  

Annals of clinical and translational neurology 20210530 7


Schwannomas are benign neoplasms that can cause gain- and loss-of-function neurological phenotypes, including severe, intractable pain. To investigate the molecular mechanisms underlying schwannoma-associated pain we compared the RNA sequencing profile of painful and non-painful schwannomas from NF2 patients. Distinct segregation of painful and non-painful tumors by gene expression patterns was observed. Differential expression analysis showed the upregulation of fibroblast growth factor 7 (FGF7  ...[more]

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