Ontology highlight
ABSTRACT:
SUBMITTER: Kukutla P
PROVIDER: S-EPMC8283170 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kukutla Phanidhar P Ahmed Sherif G SG DuBreuil Daniel M DM Abdelnabi Ahmed A Cetinbas Murat M Fulci Giulia G Aldikacti Berent B Stemmer-Rachamimov Anat A Plotkin Scott R SR Wainger Brian B Sadreyev Ruslan I RI Brenner Gary J GJ
Annals of clinical and translational neurology 20210530 7
Schwannomas are benign neoplasms that can cause gain- and loss-of-function neurological phenotypes, including severe, intractable pain. To investigate the molecular mechanisms underlying schwannoma-associated pain we compared the RNA sequencing profile of painful and non-painful schwannomas from NF2 patients. Distinct segregation of painful and non-painful tumors by gene expression patterns was observed. Differential expression analysis showed the upregulation of fibroblast growth factor 7 (FGF7 ...[more]