Electrospun wound dressings containing bioactive natural products: physico-chemical characterization and biological assessment.

ABSTRACT:

Background

Current research on skin tissue engineering has been focusing on novel therapies for the effective management of chronic wounds. A critical aspect is to develop matrices that promote growth and uniform distribution of cells across the wound area, and at the same time offer protection, as well as deliver drugs that help wound healing and tissue regeneration. In this context, we aimed at developing electrospun scaffolds that could serve as carriers for the bioactive natural products alkannin and shikonin (A/S).

Methods

A series of polymeric nanofibers composed of cellulose acetate (CA) or poly(ε-caprolactone) (PCL) and varying ratios of a mixture of A/S derivatives, has been successfully fabricated and their physico-chemical and biological properties have been explo

SUBMITTER: Arampatzis AS 

PROVIDER: S-EPMC8284004 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature