Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing.

ABSTRACT:

Key points

Healthy older adults exhibit lower cardiorespiratory fitness ( V̇O2peak ) than young in the absence of any age-related difference in skeletal muscle mitochondrial capacity, suggesting central haemodynamics plays a larger role in age-related declines in V̇O2peak . Total physical activity did not differ by age, but moderate-to-vigorous physical activity was lower in older compared to young adults. Moderate-to-vigorous physical activity is associated with V̇O2peak and muscle oxidative capacity, but physical inactivity cannot entirely explain the age-related reduction in V̇O2peak .

Abstract

Declining fitness ( V̇O2peak ) is a hallmark of ageing and believed to arise from decreased oxygen delivery and reduced muscle oxidative capacity. Physical activity is a modifiable

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8284426 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature