Antibiotic Cycling Reverts Extensive Drug Resistance in Burkholderia multivorans.

ABSTRACT: Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans. Here, we observed that treatment of extensively drug-resistant variants evolved from a cystic fibrosis (CF) sputum sample isolate with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans.

SUBMITTER: Kavanaugh LG 

PROVIDER: S-EPMC8284468 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature