Unknown

Dataset Information

0

Antibiotic Cycling Reverts Extensive Drug Resistance in Burkholderia multivorans.


ABSTRACT: Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans. Here, we observed that treatment of extensively drug-resistant variants evolved from a cystic fibrosis (CF) sputum sample isolate with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans.

SUBMITTER: Kavanaugh LG 

PROVIDER: S-EPMC8284468 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8759574 | biostudies-literature
| S-EPMC6978779 | biostudies-literature
| S-EPMC5400377 | biostudies-literature
| S-EPMC6153817 | biostudies-literature
| S-EPMC5488925 | biostudies-literature
| S-EPMC4981952 | biostudies-literature
| S-EPMC87345 | biostudies-literature
2018-06-22 | GSE111467 | GEO
2011-08-22 | GSE28306 | GEO
2011-08-22 | GSE30402 | GEO