Regional excitation-inhibition balance predicts default-mode network deactivation via functional connectivity.

ABSTRACT: Deactivation of the default mode network (DMN) is one of the most reliable observations from neuroimaging and has significant implications in development, aging, and various neuropsychiatric disorders. However, the neural mechanism underlying DMN deactivation remains elusive. As the coordination of regional neurochemical substrates and interregional neural interactions are both essential in support of brain functions, a quantitative description of how they impact DMN deactivation may provide new insights into the mechanism. Using an n-back working memory task fMRI and magnetic resonance spectroscopy, we probed the pairwise relationship between task-induced deactivation, interregional functional connectivity and regional excitation-inhibition balance (evaluated by glutamate/GABA ratio) in t

SUBMITTER: Gu H 

PROVIDER: S-EPMC8284909 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature